What is Salvestrol
On this page we publish scientific studies and documents about Salvestrolen and its application in cancer.
Important! Cancer belongs in the hands of experts. This page serves as an information portal for interested people and specialists.
Salvestroles belong to the class of vital plant substances (secondary plant substances) that are metabolised in cancer cells in humans by the tumour cell-specific enzyme CYP1B1 and thereby trigger a number of different processes up to cell death, which then lead to a standstill or even a decrease in cancer.
The high-dose original composition with 2000 Salvestrol points and a new, lower-dose composition with 350 Salvestrol points are the original products from the manufacturer. The manufacturer uses the following.
Inside fruits and vegetables, salvestroles are part of the defence mechanism of plants. Salvestrols are phytoalexins whose formation is triggered by invading pathogens. If, for example, a ripe fruit is attacked by a fungus, the synthesis of a salvestrol specific for this pathogen is triggered. Salvestrols are formed at the site, usually in the fruit’s skin or in the root of the plant, and penetrates the pathogen.
We use salvestrols to get rid of carcinomatous degenerated cells. Unfortunately, salvestrols are not produced by the body itself, but industrially processed foods contain only small amounts of salvestrols and other useful plant nutrients, and this decline may be due to the ever-increasing number of cancer cases in the developed world. The salvestrols content in our food is massively reduced by modern farming methods.
Salvestrols are contained in various fruits and vegetables. For example, in pumpkin, blackberries or oranges. It is important that the natural products have not been treated with pesticides to maintain the salvestrol content.
Prof. Dr. Dan Burke
The defense mechanism of salvestrols
The defence mechanism of salvestrols shows a number of pleasing properties.
1. It does no harm. The toxic substances created by the metabolism of salvestroles by CYP1B1 are found exclusively in the cancer cells and are consumed when the cells are destroyed.
2. The mechanism is based on nutrients; it depends exclusively on enzymatic activation and certain factors that should also be part of our daily diet.
3. The mechanism reveals a clear and easily understandable relationship between diet and cancer, which can serve as an incentive for dietary change.
4. CYP1B1 is now widely regarded as a universal cancer marker due to its ubiquitous presence in various cancers. Because of its universality, the same defence mechanism can be used regardless of the origin of the cancer.eingesetzt werden.
Salvestrols in food
Our food needs are complex and a defence mechanism cannot function in complete isolation. Therefore factors are important which maximize the effectiveness of salvestrols. First and foremost, this includes a change in diet to products from organic farming. This not only reduces the intake of potential cytochrome P450 inhibitors, but also improves the supply of salvestrols and useful vital substances.
Physical exercise is also important to ensure that enough oxygen is available, which is needed for the optimal metabolic activity of CYP1B1. In short: Paying attention to a good diet supports the defence mechanism to a high degree.
Salvestrols products
The high-dose original composition with 2000 Salvestrol points and a new, lower-dose composition with 350 Salvestrol points are the original products from the manufacturer. The manufacturer uses the following Salvestrol logo on the product. It is important not to buy just any Salvestrol product, but only the original.
The salvestrol points are a unit of measurement for the amount of salvestrol given with one capsule. The minimum recommended daily intake is estimated to be 100 points. A person with a body weight between 77 and 84 kg should take 4200 points daily as the maximum dose for therapeutic use.
Literature on the subject of salvestrol
Dr. Brian Schaefer has written an excellent work in the book Salvestrols: Natures Defence against cancer (3rd edition), which is recommended to all professionals who are more deeply involved with the topic of salvestrole in therapy. The book is available on Amazon as well as from your bookseller.
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Salvestrol Studies
The secondary plant compounds of salvestroles have already been investigated in several studies. Here we publish the list of studies concerning CYP1B1 and the salvestroles. It is exciting to see the diversity of the studies.
against the Major Xenobiotic Metabolising Forms of
Cytochrome P450 in Humans Herunterladen
in Breast Cancer with Monoclonal Antibodies
Specific for CYP1B1 Herunterladen
cytochrome P4501B1 expressions in human
non-small cell lung cancers Herunterladen
Colon Adenocarcinomas Relative to Normal Colon:
Implications for Drug Development Herunterladen
by specific cytotoxic T cells Herunterladen
P450 CYP1B1/CYP1A1 signalling pathway Herunterladen
CARCINOMA WITH PROTEIN EXPRESSION IN ASSOCIATED
HYPERPLASTIC AND PREMALIGNANT TISSUE Herunterladen
to the UniversalTumorAntigen CYP1B1and
Response to Next Therapy Herunterladen
Identification of PrognosticMarkers Herunterladen
Asn453Ser Polymorphism on the Post-Translational Regulation
of CYP1B1 Expression Herunterladen
Hypomethylation in Prostate Cancer Herunterladen
early diagnosis and prevention of colorectal cancer Herunterladen
in human breast carcinomas Herunterladen
for CYP1B1Up-Regulation and Cell Growth in Human
LungAd enocarcinomas Herunterladen
with adenocarcinoma of the breast: correlation with
menopausal status and histological grade Herunterladen
Non-small Cell Lung Cancer: A Potential Therapeutic Target Herunterladen
What is CYP1B1?
Cytochrome P450 1B1 (CYP1B1) is an extrahepatic, drug-degrading enzyme. Recent advances at the Dana-Farber Cancer Institute have shown that CYP1B1 is overexpressed in all primary human tumours and minimally expressed in normal critical tissues. This invention provides methods both for the immunotherapeutic targeting of CYP1B1-expressing cells and for monitoring the progress of this approach.
This technology can be used either for the treatment of pre-existing cancers (including bladder, brain, colon, lung and kidney) or as a prophylactic measure to prevent disease occurrence or recurrence in patients at risk. In both cases, immunotherapy is initially based on antigen-presenting cells that take up and process the protein or peptide antigen CYP1B1; a series of subsequent events leads to the activation of cytotoxic T lymphocytes (CTLs), the target cells that express the antigen, multiply and kill.
Therapy progress can be monitored by contrasting CYP1B1-specific CTL values with those from the pre-vaccinated (or pre-stimulated in ex vivo methods) state.
Applications/advantages
Cancer therapeutics usually do not differentiate between cancer and normal cells, which leads to considerable toxicity. Since CYP1B1 expression is limited in normal tissue and strongly expressed in human cancers, immunotherapy against CYP1B1-expressing cells is much more specific.
Furthermore, in contrast to several epitopes in other tumour-associated antigens, CYP1B1 contains epitopes that are characterised by a high binding affinity for the large histocompatibility complex (MHC); MHC binding and MHC peptide complex stability are important parameters that influence the immunogenicity of MHC peptides
Salvestrol Synergisten
Salvestrol has natural synergists which enhance the effect of salvestrols.
Biotin (vitamin H) promotes the production of CYP enzymes, including CYP1B1, while magnesium and niacin stimulate the salvestrols activation mechanism Iron forms the core of the CYP1B1 enzyme, and vitamin C protects salvestrols from premature oxidation and potentially provides CYP1B1 with electrons needed for metabolic conversion.
Here again the list of synergists for salvestrols:
- Biotin
- Magnesium
- Vitamin B3
- Iron
- Vitamin C
Attention! The effect of salvestrole is affected by vitamin B17. In therapies with apricot kernels, salvestrol must not be used at the same time.
Medical Advice
For medical questions regarding the integrative treatment of cancer or further information on salvestroles and their application, please contact the following office:
Wise Medicine
Sulzerallee 46
8404 Winterthur
Switzerland
Cancer Specialists:
Dr. med. H. Lüscher
Tel. +41 44 545 29 10 (appointment requests)
info@wisemed.ch